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MMP Polymorphisms and Acute Coronary Syndromes

NCT00484406 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2007-06-08

No results posted yet for this study

Summary

Some Matrix Metalloproteases, proteases degrading the extracellular matrix, play a relevant role in structure and stability of atherosclerotic plaques. Atherosclerotic plaques triggering acute coronary syndromes show increased expression of MMP-1, MMP-3 and MMP-9. Regulation of these MMPs is plaid by genetic polymorphisms, G+/G- at -1563 for MMP-1, 4A/5A- at -1612 for MMP-3, and a microsatellite (13-27 CA repeats around -90) for MMP-9.

It is conceivable that these polymorphisms correlate with the clinical outcome of acute coronary syndromes, particularly with those without ST segment Elevation (NSTEACS).

Conditions

  • Unstable Angina

Sponsors & Collaborators

  • University of Trieste

    lead OTHER

Principal Investigators

  • Nicola FIOTTI, MD · University of Trieste, ITALY

  • Carlo Giansante, MD · University of Trieste, ITALY

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-02-28
Completion
2007-05-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00484406 on ClinicalTrials.gov