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The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-grade Astrocytomas

NCT00473408 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 1

Last updated 2016-12-06

No results posted yet for this study

Summary

The purpose of the current trial is to explore whether the standard treatment with radiotherapy and temozolomide affect the tumor vasculature in patients with high-grade astrocytomas. If vascular effects are identified, future clinical trials can be proposed wherein anti-angiogenic agents are added to increase patient survival.

Conditions

Interventions

DEVICE

Functional MRI (DCE-MRI)

MRI examination with i.v. gadolinium contrast to assess blood perfusion in remaining tumor tissue.

PROCEDURE

Blood sample

See protocol.

PROCEDURE

Tumor sample

See protocol.

Sponsors & Collaborators

  • University of Bergen

    collaborator OTHER

  • Haukeland University Hospital

    lead OTHER

Principal Investigators

  • Hans Petter Eikesdal, MD PhD · Institute of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-03-31
Primary Completion
2007-05-31
Completion
2011-11-30

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00473408 on ClinicalTrials.gov