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Study to Test Genetic Alterations Among Different Dermoscopic Types of Melanocytic Nevi.

NCT00422448 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2011-01-14

Study results available
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Summary

This project is a multicenter study in which we will investigate a dual concept of nevogenesis. Study location is the Department of Dermatology at the Medical University of Graz in collaboration with centers in Austria (Vienna), Italy (Naples, Benevento, Modena), Spain (Barcelona) and the United States (New York).

The hypothesis is that small congenital melanocytic nevi (CMN), "early" acquired melanocytic nevi in childhood (AMN) and dermal nevi, all dermatoscopically characterized by globular pattern, belong to the same spectrum of genetically determined melanocytic proliferations that develop due to endogenous pathways, in contrast to "true" acquired melanocytic nevi, dermatoscopically showing reticular pattern, that develop due to exogeneous factors such as UV-exposure.

Conditions

  • Nevi

Interventions

GENETIC

To test the frequency of BRAF and NRAS mutations among nevi

Benign nevi excised for the study purpose where genetically analyzed for the presence/absence of BRAF and NRAS mutations

Sponsors & Collaborators

  • Medical University of Graz

    lead OTHER

Principal Investigators

  • Iris Zalaudek, MD · Department of Dermatology, Medical University of Graz

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
9 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-09-30
Primary Completion
2009-03-31
Completion
2010-04-30

Countries

  • Austria

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00422448 on ClinicalTrials.gov