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Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients Having a Tonsillectomy

NCT00378547 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 147

Last updated 2010-01-01

No results posted yet for this study

Summary

Patients scheduled for a tonsillectomy need postoperative pain treatment. Some of the most widely used postoperative analgetics (NSAIDs) sometimes cause rebleeding in the postoperative period, and another often used analgetic, morphine, causes nausea and vomiting. The researchers therefore will investigate new combinations of postoperative analgesics in hopes of improving pain and the need for opioids during the postoperative period.

Conditions

  • Pain, Postoperative

Interventions

DRUG

paracetamol + placebo + placebo

Comparing the analgesic effect of combinations of paracetamol + placebo + placebo

DRUG

paracetamol + pregabalin + placebo

Comparing the analgesic effect of combinations of paracetamol + pregabalin 300 mg + placebo

DRUG

paracetamol + pregabalin + dexamethasone

Comparing the analgesic effect of combinations of paracetamol + pregabalin 300 mg + dexamethasone 8 mg

Sponsors & Collaborators

  • Glostrup University Hospital, Copenhagen

    lead OTHER

Principal Investigators

  • Ole Mathiesen, MD · Department of Anaesthesiology, Copenhagen University Hospital in Glostrup, 2600 Glostrup, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-01-31
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00378547 on ClinicalTrials.gov