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The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

NCT00373919 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2007-03-05

No results posted yet for this study

Summary

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy.

Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence.

Design: This is a prospective, randomized, double blind, placebo controlled study.

Number of patients: 30.

Inclusion Criteria:

* Patients after trans-hiatal esophagectomy

Exclusion Criteria:

* Allergy to erythromycin
* Use of phenothiazine
* QT prolongation
* Liver function test (LFT) abnormalities
* Myasthenia gravis
* Cardiomyopathy

Conditions

  • Esophagectomy
  • Postoperative Complications

Interventions

DRUG

intravenous (IV) administration of erythromycin

Sponsors & Collaborators

  • Kaplan Medical Center

    lead OTHER

Principal Investigators

  • Koram Klein, MD · Kaplan Medical Center

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00373919 on ClinicalTrials.gov