Belinostat in Treating Patients With Myelodysplastic Syndromes
NCT00357162 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 21
Last updated 2014-05-20
Summary
This phase II trial is studying how well belinostat works in treating patients with myelodysplastic syndromes. Belinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer.
Conditions
- de Novo Myelodysplastic Syndromes
- Previously Treated Myelodysplastic Syndromes
- Secondary Myelodysplastic Syndromes
Interventions
- DRUG
-
belinostat
Given IV
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Amanda Cashen · Mayo Clinic
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-05-31
- Primary Completion
- 2010-12-31
- Completion
- 2010-12-31
Countries
- United States
Study Locations
More Related Trials
-
CPX-351 Therapy for MDS After Hypomethylating Agent Failure
NCT03957876 ·Status: TERMINATED ·Phase: PHASE2
-
AZD2171 in Treating Patients With Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia
NCT00321724 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase I Pilot Study of Abaloparatide + Bevacizumab in Myelodysplastic Syndromes
NCT03746041 ·Status: COMPLETED ·Phase: PHASE1
-
Testing the Safety and Efficacy of the Combination of the Antibody Pembrolizumab and Entinostat in Patients With Myelodysplastic Syndrome Who Are Not Responding to Hypomethylating Agents
NCT02936752 ·Status: COMPLETED ·Phase: PHASE1
-
Dolastatin 10 in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia
NCT00003693 ·Status: COMPLETED ·Phase: PHASE1
-
Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT00816595 ·Status: COMPLETED ·Phase: PHASE2
-
Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm
NCT05600894 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Palbociclib and Dexamethasone in Treating Participants With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia
NCT03472573 ·Status: COMPLETED ·Phase: PHASE1
-
Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Other B-cell Cancers
NCT00003658 ·Status: COMPLETED ·Phase: PHASE2
-
MS-275 in Treating Patients With Hematologic Cancer
NCT00015925 ·Status: COMPLETED ·Phase: PHASE1
-
SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes
NCT00098826 ·Status: COMPLETED ·Phase: PHASE1
-
The Role of Erlotinib an Epidermal Growth Factor Receptor (EGFR) Inhibitor in the Treatment of Myelodysplastic Syndrome
NCT00570375 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems
NCT03814005 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluating the Efficacy and Safety of Bemcentinib in Patients With Myelodysplastic Syndromes
NCT03824080 ·Status: COMPLETED ·Phase: PHASE2
-
Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic Syndrome
NCT05673057 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia
NCT01670084 ·Status: WITHDRAWN ·Phase: PHASE2
-
STI571 Plus Cytarabine in Treating Patients With Chronic Myelogenous Leukemia
NCT00015834 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Chronic Phase Who Are Refractory to Imatinib Mesylate (Gleevec)
NCT00042016 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Combination With Low Intensity Chemotherapy in Older Patients With Newly Diagnosed B-cell Acute Lymphoblastic Leukemia
NCT07153796 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study of Weekly Motexafin Gadolinium (MGd) for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT00290004 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Pentostatin, and Rituximab With and Without Cyclophosphamide for Previously Untreated B-Chronic Lymphocytic Leukemia
NCT00201721 ·Status: COMPLETED ·Phase: PHASE2
-
CPI-613 in Treating Patients With Myelodysplastic Syndromes Who Failed Previous Therapy
NCT01902381 ·Status: TERMINATED ·Phase: PHASE2
-
MS-275 and Azacitidine in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia
NCT00101179 ·Status: COMPLETED ·Phase: PHASE1
-
Erlotinib Study for Myelodysplastic Syndrome (MDS)
NCT00977548 ·Status: COMPLETED ·Phase: PHASE2
-
STI571 Plus Combination Chemotherapy in Treating Patients With Chronic Myelogenous Leukemia or Acute Lymphocytic Leukemia
NCT00015860 ·Status: COMPLETED ·Phase: PHASE1/PHASE2