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The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes

NCT00337298 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2009-06-23

No results posted yet for this study

Summary

The purpose of this study is to compare the effect of two antihypertensive drugs on retinal vessel diameter in young type 1 diabetics. The retinal vessel analyzer (RVA) was used to investigate how the drugs affected vessel diameter, when the subjects were exposed to an increase in blood pressure, induced by isometric muscle contraction and when they were stimulated by flickering light.

Conditions

Interventions

DRUG

Amlodipine

1 (5mg) tablet daily, given 14 days totally before measure of outcome.

DRUG

Lisinopril

Lisinopril 10 mg given daily for 14 days and then outcome was measured.

Sponsors & Collaborators

  • Velux Fonden

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Toke Bek, MD, PhD · Aarhus university hospital, Dep. of ophthalmology

  • Per L Poulsen, MD, PhD · Aarhus University hospital, Dep. of endocrinology (M)

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2009-02-28
Completion
2009-02-28

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00337298 on ClinicalTrials.gov