Effects Of Rosiglitazone (Extended Release Tablets) On Cerebral Glucose Utilisation And Cognition Alzheimers Disease
NCT00334568 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2013-01-14
Summary
Clinical features in patients with the familial early onset forms and the sporadic forms of Alzheimers disease are similar, although the course of deterioration may be different. It would be very informative to examine the drug response of patients with Alzheimers disease by a certain genotype to find evidence favouring genotype-specific drug responses that may indicate genetically defined phenotypic differences in alzheimers disease.
Conditions
Interventions
- DRUG
-
Rosiglitazone XR (extended release) oral tablets
Rosi XR tablets
- DRUG
-
Placebo
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
GSK Clinical Trials · GlaxoSmithKline
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 50 Years
- Max Age
- 85 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2004-12-31
- Primary Completion
- 2007-07-31
- Completion
- 2007-07-31
Countries
- United Kingdom
Study Locations
More Related Trials
-
Open-Label Extension Assessing Long-Term Safety Of Rosiglitazone In Subjects With Mild To Moderate Alzheimer's Disease
NCT00381238 ·Status: COMPLETED ·Phase: PHASE2
-
Mild Alzheimer''s Disease to Assess the of Extended Release Formulation of Rosiglitazone (RSG XR)
NCT00688207 ·Status: COMPLETED ·Phase: PHASE1
-
Rosiglitazone Effects on Cognition for Adults in Later Life
NCT00242593 ·Status: UNKNOWN ·Phase: PHASE2
-
Insulin, Neurogenetics and Memory in Alzheimer's Disease
NCT00018382 ·Status: COMPLETED ·Phase: PHASE2
-
Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset
NCT01931566 ·Status: TERMINATED ·Phase: PHASE3
-
Efficacy and Safety of PRJ212 to Improve the Memory of Patients With Mild Severity Alzheimer's Disease
NCT02991235 ·Status: UNKNOWN ·Phase: NA
-
AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease
NCT02284906 ·Status: TERMINATED ·Phase: PHASE3
-
Pioglitazone in Alzheimer Disease
NCT00982202 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo
NCT02957682 ·Status: COMPLETED ·Phase: PHASE4
-
A Study to Assess the Safety of GRF6019 Infusions in Subjects With Severe Alzheimer's Disease
NCT03765762 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Azeliragon in Patients With Mild Alzheimer's Disease and Impaired Glucose Tolerance
NCT03980730 ·Status: TERMINATED ·Phase: PHASE2
-
A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD)
NCT06402838 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
4 Week, Safety and Tolerability Study in Patients With Mild to Moderate Alzheimer's Disease
NCT01039701 ·Status: COMPLETED ·Phase: PHASE2
-
Proof of Concept Study of Cognitive Improvement in Patients With Alzheimer's Disease
NCT00501111 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of RO5313534 as Add-on to Donepezil Treatment in Patients With Mild to Moderate Alzheimer's Disease
NCT00884507 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
NCT03131453 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
Study of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type
NCT00104013 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease
NCT06079190 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Phase 3 Study of Rotigotine in Combination with Rivastigmine in Mild to Moderate Alzheimer's Disease
NCT06702124 ·Status: RECRUITING ·Phase: PHASE3
-
Safety Study of a Glycogen Synthase Kinase 3 (GSK3) Inhibitor in Patients With Alzheimer´s Disease
NCT00948259 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Repeated Dose Study of KHK6640 in Japanese Patients With Alzheimer's Disease
NCT03093519 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Alzheimer's Disease
NCT03090516 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Extension Study of Participants From SPG302-ALZ-101
NCT06833281 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of RO7105705 in Healthy Participants and Participants With Mild-to-Moderate Alzheimer's Disease
NCT02820896 ·Status: COMPLETED ·Phase: PHASE1
-
Rasagiline Rescue in Alzheimer's Disease Clinical Trial
NCT02359552 ·Status: COMPLETED ·Phase: PHASE2