Assessment of Tramadol as a Treatment for Opioid Addiction
NCT00301210 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 9
Last updated 2015-04-17
Summary
Opioids are one of the most commonly abused drugs among individuals who seek treatment for drug abuse. Thus, it is necessary to develop new treatments for opioid addiction. The purpose of this trial is determine whether tramadol is effective in treating opioid dependent individuals.
Conditions
- Opioid-Related Disorders
Interventions
- DRUG
-
Tramadol
oral doses four times per day
Sponsors & Collaborators
-
National Institute on Drug Abuse (NIDA)
collaborator NIH - lead OTHER
Principal Investigators
-
Eric C. Strain, MD · Johns Hopkins University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- TRIPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 21 Years
- Max Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-01-31
- Primary Completion
- 2007-10-31
- Completion
- 2007-11-30
Countries
- United States
Study Locations
More Related Trials
-
A Study to Compare the Bioavailability of Two Tramadol Hydrochloride Tablet Products (50 mg and 200 mg, Respectively) at Steady-state Under Fasting Conditions
NCT00834288 ·Status: COMPLETED ·Phase: PHASE1
-
Comparison of Tramadol Orally Versus an Optimized Dose of Intravenous Tramadol for Postoperative Pain Relief in Ambulatory Surgery
NCT00735748 ·Status: COMPLETED ·Phase: PHASE4
-
PK PD of the Enantiomers of Tramadol and O-desmethyltramadol in Elderly and Young Subjects
NCT02329561 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Increased Pain Tolerance on Exercise Performance
NCT03934411 ·Status: COMPLETED ·Phase: NA
-
Comparative Bioavailability Between Two Tramadol Formulations: Study of the Better Controlled Release of a New 200 mg Once A Day (OAD) Formulation Versus Zytram® 200 mg
NCT00911742 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Compare the Relative Bioavailability of Two 200 Mg Tramadol Hydrochloride Tablet Products Under Fasting Conditions
NCT00834366 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluate Safety of Tramadol in the Management of Postoperative Pain Following Surgery
NCT03395808 ·Status: COMPLETED ·Phase: PHASE3
-
A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers
NCT01947920 ·Status: COMPLETED ·Phase: PHASE1
-
Cognitive Function and Addiction Under Opioid Tapering
NCT03365817 ·Status: COMPLETED ·Phase: PHASE3
-
Tramadol iv. : Influence of Dose and Dose Intervals on Therapeutic Accuracy and Side Effects When Used for Postoperative Pain Relief in Ambulatory Surgery
NCT00333346 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Comparing the Effectiveness and Safety of Extended-release Tramadol Versus Placebo in the Treatment of Chronic Low Back Pain
NCT00347724 ·Status: COMPLETED ·Phase: PHASE3
-
A One-year, Open-label Study to Assess the Safety and Effectiveness of Extended Release Tramadol HCl in the Treatment of Chronic, Non-malignant Pain.
NCT00347685 ·Status: COMPLETED ·Phase: PHASE3
-
Omnitram Pharmacokinetic Study In Healthy Volunteers
NCT02205554 ·Status: COMPLETED ·Phase: PHASE1
-
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol OAD Tablets to Twice Daily Tramadol BID for the Treatment of Osteoarthritis of the Knee (Extension Protocol) and Open Label Safety Follow-Up
NCT00912015 ·Status: COMPLETED ·Phase: PHASE3
-
A Dose Linearity Study of the Labopharm Formulation of Tramadol HCl/Contramid®, 100 mg, 200 mg and 300 mg After A Single Oral Administration In Fasting Condition, In Healthy Human Volunteers
NCT00834808 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.
NCT05587998 ·Status: COMPLETED ·Phase: PHASE1
-
Inflammation and Postoperative Tramadol Analgesia
NCT04330157 ·Status: COMPLETED
-
A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy
NCT01443403 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Itraconazole and Ticlopidine on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol
NCT01214941 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Duloxetine and Venlafaxine on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol: A Three-phase Randomized Balanced Cross-over Study in Healthy Volunteers
NCT01443520 ·Status: COMPLETED ·Phase: PHASE4
-
Tramadol for Labor Analgesia: a Placebo Controlled Randomised Control Trial
NCT02999594 ·Status: UNKNOWN ·Phase: PHASE2
-
Pain Relief - Tramadol Versus Ibuprofen
NCT00111046 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
An Open-Label Long-term Safety Study of Tramadol HCl OAD (Once A Day) 300 mg in the Treatment of Pain Due to Osteoarthritis of the Knee
NCT00833911 ·Status: COMPLETED ·Phase: PHASE3
-
An Exploratory Study of Tramadol Hydrochloride in Patients With Osteoarthritis of the Knee or Low Back Pain
NCT00752661 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament
NCT00236535 ·Status: COMPLETED ·Phase: PHASE3