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Long-term Impact of Pneumococcal Conjugate Vaccine on Carriage

NCT00294021 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2012-09-26

No results posted yet for this study

Summary

Pneumococcus is a major cause of morbidity and mortality. In 2000, a pneumococcal conjugate vaccine (PCV) was licensed for use in children and is now part of the routine childhood vaccine schedule. PCV is known to reduce invasive disease and protect against nasopharyngeal (NP) acquisition of vaccine serotype pneumococci; it also results in an increased risk of nonvaccine serotype carriage. This study proposes to assess the longterm impact of vaccine on NP carriage in a setting where there is intense antibody pressure on the ecology of the pneumococcus. A cross sectional study of pneumococcal NP colonization among American Indian children will be combined with surveillance for invasive disease in the same population. The purpose is to determine the impact of community wide PCV use on NP colonization and the relationship with invasive disease. This longterm safety issue needs to be assessed to fully evaluate the impact of vaccine on NP ecology and invasive disease.

Conditions

  • Pneumococcal Infections

Sponsors & Collaborators

  • Centers for Disease Control and Prevention

    collaborator FED

  • Institute of Child Health

    collaborator OTHER

  • Finnish Public Health Institute

    collaborator UNKNOWN

  • Thrasher Research Fund

    collaborator OTHER

  • Grand Challenges in Global Health

    collaborator OTHER

  • Johns Hopkins Bloomberg School of Public Health

    lead OTHER

Principal Investigators

  • Katherine L O'Brien, MD, MPH · Johns Hopkins Center for American Indian Health

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-03-31
Completion
2008-04-30

Countries

  • United States

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00294021 on ClinicalTrials.gov