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REPAIR-AMI: Intracoronary Progenitor Cells in Acute Myocardial Infarction (AMI)

NCT00279175 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 204

Last updated 2012-09-20

No results posted yet for this study

Summary

Impaired contractile function after a heart attack of the heart is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy, including immediate balloon/stent dilation of the infarct vessel.

The aim of the REPAIR-AMI trial is to investigate whether infusion of progenitor cells into the infarct vessel (after successful reperfusion therapy) may improve left ventricular contractile function compared to placebo therapy. After bone marrow aspiration progenitor cells are enriched via a centrifugation method.

Conditions

Interventions

BIOLOGICAL

Intracoronary infusion of enriched bone marrow-derived progenitor cells

BIOLOGICAL

Placebo medium supplemented with autologous serum

Sponsors & Collaborators

  • Johann Wolfgang Goethe University Hospital

    collaborator OTHER

  • Blutspendedienst Baden-Württemberg - Hessen

    collaborator UNKNOWN

  • Guidant Corporation

    collaborator INDUSTRY

  • Eli Lilly and Company

    collaborator INDUSTRY

  • A. M. Zeiher

    lead OTHER

Principal Investigators

  • Andreas M Zeiher, MD · J. W. Goethe University Hospitals

  • Volker Schächinger, MD · J. W. Goethe University Hopspitals

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-04-30
Primary Completion
2005-10-31
Completion
2010-12-31

Countries

  • Germany
  • Switzerland

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00279175 on ClinicalTrials.gov