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Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma

NCT00279136 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2006-01-19

No results posted yet for this study

Summary

Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration. This protects healthy subjects against bronchoconstrictive stimuli, and reverses pre-existing bronchoconstriction. However, the deep breath-induced bronchoprotection and -bronchodilation is impaired in asthma. We questioned whether this is specific for asthma (in comparison to COPD), and whether this is associated with bronchial inflammation and -remodelling. The study is a two-groups comparison, of physiological and pathological disease markers, obtained by methacholine challenges, monitoring airways resistance, and by taking bronchial biopsies.

Conditions

Sponsors & Collaborators

  • The Netherlands Asthma Foundation

    collaborator OTHER

  • Leiden University Medical Center

    lead OTHER

Principal Investigators

  • Peter J. Sterk, MD, PhD · Leiden University Medical Center

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-09-30
Completion
2006-03-31

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00279136 on ClinicalTrials.gov