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Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance

NCT00277342 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2012-05-04

No results posted yet for this study

Summary

The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin resistance. In the present study the investigators will investigate potential differences in lipid-induced hepatic insulin resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy subjects with the A277G polymorphism vs. subjects carrying the wildtype.

Conditions

  • Wildtype
  • Polymorphism Liver FABP

Interventions

PROCEDURE

measurement of lipid-induced hepatic insulin resistance

Sponsors & Collaborators

  • German Institute of Human Nutrition

    lead OTHER

Principal Investigators

  • Martin O Weickert, MD · German Institute of Human Nutrition; Charité Campus Benjamin Franklin

  • Matthias Möhlig, MD · German Institute of Human Nutrition; Charité Campus Benjamin Franklin

  • Andreas FH Pfeiffer, MD · German Institute of Human Nutrition; Charité Campus Benjamin Franklin

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-31
Completion
2006-04-30

Countries

  • Germany

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00277342 on ClinicalTrials.gov