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Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin

NCT00240513 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2012-02-24

No results posted yet for this study

Summary

The use of oral antibiotics alone to treat inflammatory acne provides little to no long term therapeutic benefit.

Acne relapse rates can be reduced by using topical tretinoin 0.01% in conjunction with minocycline, thereby increasing the therapeutic effect of the oral antibiotic.

Conditions

  • Acne Vulgaris

Interventions

DRUG

Minocycline

100 mg capsules OD for 3 months

DRUG

Minocycline plus tretinoin

100mg OD Minocycline for 12 weeks plus OD Topical tretinoin 0.01% for 12 weeks Followed by topical tretinoin 0.01% OD for 12 weeks alone

Sponsors & Collaborators

  • Stiefel, a GSK Company

    collaborator INDUSTRY

  • Derm Research @ 888 Inc.

    lead INDUSTRY

Principal Investigators

  • Richard Thomas, MD, FRCP(C) · DermResearch @ 888 Inc.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-08-31
Primary Completion
2006-12-31
Completion
2006-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00240513 on ClinicalTrials.gov