Ketamine on Acute Pain in Females and Males

Summary

The purpose of the study is to determine whether equal subanesthetic doses of racemic ketamine is equally effective on females and males after surgical removal of third molars

Conditions

• Mouth and Tooth Diseases
• Tooth, Impacted

Interventions

DRUG

Placebo males

Intravenous saline bolus (Placebo-control) males

DRUG

Ketamine 0,1 mg/kg males

0,1 mg/kg ketamine iv bolus males

DRUG

Ketamine 0,3 mg/kg males

0,3 mg/kg ketamine iv bolus males

DRUG

Ketamine 0,5 mg/kg males

0,5 mg/kg ketamine iv bolus males

DRUG

Placebo females

Intravenous saline bolus (Placebo-control) females

DRUG

Ketamine 0,1 mg/kg females

0,1 mg/kg iv bolus ketamine females

DRUG

Ketamine 0,3 mg/kg females

0,3 mg/kg iv bolus ketamine females

DRUG

Ketamine 0,5 mg/kg females

0,5 mg/kg iv bolus ketamine females

Sponsors & Collaborators

• University of Oslo

  collaborator OTHER

• Ullevaal University Hospital

  lead OTHER

Principal Investigators

• Lasse A Skoglund, DDS, PhD · Section of Dental Pharmacology and Pharmacotherapy, Faculty of Dentistry, POB 1119 Blindern, University of Oslo, N-0317 Oslo, Norway

• Olav Hustveit, MD · Section of Dental Pharmacology and Pharmacotherapy, Faculty of Dentistry, POB 1119 Blindern, University of Oslo, N-0317 Oslo, Norway

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2005-01-31

Primary Completion

2006-11-30

Completion

2006-11-30

Countries

• Norway

Study Locations