Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage

Summary

The purpose of the study is to determine whether lowering high blood pressure levels after the start of a stroke caused by bleeding in the brain (intracerebral haemorrhage) will reduce the chances of a person dying or surviving with a long term disability. The study will be undertaken in two phases: a vanguard phase in 400 patients, to plan for a main phase in 2000 patients.

Conditions

• CVA (Cerebrovascular Accident)
• Cerebral Hemorrhage
• Intracranial Hemorrhages

Interventions

DRUG

Labetalol Hydrochloride

DRUG

Metoprolol tartrate

DRUG

Hydralazine Hydrochloride

DRUG

Glycerol Trinitrate

DRUG

Phentolamine mesylate

DRUG

Nicardipine

DRUG

Urapidil

DRUG

Esmolol

DRUG

Clonidine

DRUG

Enalaprilat

DRUG

Nitroprusside

Sponsors & Collaborators

• National Health and Medical Research Council, Australia

  collaborator OTHER

• The George Institute

  lead OTHER

Principal Investigators

• Craig Anderson, PhD · The George Institute

• Bruce Neal, PhD · The George Institute

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2005-11-30

Primary Completion

2007-09-30

Completion

2007-09-30

Countries

• Australia
• China
• New Zealand

Study Locations