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Effects of Keppra on Thinking, Emotions, and Balance in Elderly Healthy Volunteers

NCT00221988 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2022-05-18

No results posted yet for this study

Summary

Epilepsy is a common disorder with an incidence of about 6 per 1000. The incidence progressively increases above age 50. By age 75, the incidence is two to three fold compared with any age group. Unfortunately, older individuals are especially at risk to incur significant side effects to anti-epileptic drugs. A newer anti-epileptic drug may markedly improve seizure management in older individuals as it is removed by the kidneys and not the liver and does not interact with other medications. We expect it to be tolerated well in terms of effects on memory, thinking,balance, and walking. The current study assesses the side effects of levetiracetam in healthy volunteers aged 65 to 80. Use of healthy volunteers eliminates the effects of seizures on the outcome.

Conditions

Interventions

DRUG

Levetiracetam (Keppra)

Sponsors & Collaborators

  • Michael Schoenberg, Ignacio Pita, Kyra Dawson

    collaborator UNKNOWN

  • University Hospitals Cleveland Medical Center

    lead OTHER

Principal Investigators

  • Mary Ann Werz, M.D., Ph.D. · University Hospitals Cleveland Medical Center

  • Mike R Schoenberg, Ph.D. · University Hospitals Cleveland Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
65 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-03-31
Primary Completion
2007-10-31
Completion
2007-10-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00221988 on ClinicalTrials.gov