MedTrace Logo

Role of Esophageal Mast Cell Activation in Noncardiac Chest Pain (NCCP)

NCT00219492 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 86

Last updated 2017-06-20

No results posted yet for this study

Summary

Chest pain is a common clinical complaint. About 30% patients with chest pain will have a normal coronary angiogram and are described as having noncardiac chest pain (NCCP). It is estimated that 25% of the population complain of chest pain at some time in their lifetime. The pathogenesis of NCCP is unknown. Esophageal hypersensitivity as a result of inflammation is considered to be an important mechanism in the development of this pain sensation. Little is currently known about the interaction between inflammatory mediators and peripheral afferent nerve terminals in the esophagus. The mast cell is one of the most enriched pro-inflammatory cells in the gastrointestinal tract. Activation of the mucosal mast cell releases a variety of mediators into adjacent tissues. We hypothesize that mediators released by mast cells sensitize esophageal nociceptors and induce pain sensation.

Conditions

  • Noncardiac Chest Pain (NCCP)

Sponsors & Collaborators

  • Milton S. Hershey Medical Center

    lead OTHER

Principal Investigators

  • Shaoyong Yu, MD, MPH · Department of Medicine, Penn State College of Medicine Hershey Medical Center

  • Ann Ouyang, MD · Penn State College of Medicine Hershey Medical Center

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-09-30
Primary Completion
2014-08-21
Completion
2014-08-21

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00219492 on ClinicalTrials.gov