German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults

Summary

This study evaluates the efficacy and tolerability of treatment for T-lymphoblastic lymphoma (T-LBL) according to a protocol for acute lymphoblastic leukemia. Patients receive one year of intensive cyclical chemotherapy with additional prophylaxis for central nervous system (CNS) relapse by intrathecal therapy and cranial irradiation and mediastinal irradiation after induction chemotherapy.

Conditions

• Lymphoma, Lymphoblastic

Interventions

DRUG

Dexamethasone/Prednisolone

DRUG

Cyclophosphamide

DRUG

Vincristine

DRUG

Daunorubicin

DRUG

Asparaginase

DRUG

G-CSF

DRUG

Mercaptopurine

DRUG

Cytarabine

DRUG

Methotrexate

DRUG

VP16

DRUG

Vindesine

DRUG

Adriamycin

DRUG

Thioguanine

DRUG

HDARAC

PROCEDURE

CNS irradiation

PROCEDURE

Mediastinal irradiation

DRUG

Cladribine

Sponsors & Collaborators

• Johann Wolfgang Goethe University Hospital

  lead OTHER

Principal Investigators

• Dieter Hoelzer, MD, PhD · University Hospital Frankfurt, Medical Dept. II

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

15 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2004-04-30

Primary Completion

2009-03-31

Countries

• Germany

Study Locations