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BlueCQ Bioavailability

NCT00176072 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 18

Last updated 2005-09-15

No results posted yet for this study

Summary

Bioavailability of methylene blue (MB) - comparison of an i.v. and two oral MB formulations - and influence of sustained release MB on chloroquine (CQ) concentrations in whole blood, plasma and urine.

Intraindividual cross over open comparison in healthy male and female individuals (6:6) with different MB formulations in randomised order for the determination of the absolute bioavailability of MB (part 1), followed by an explorative randomised parallel group comparison of CQ disposition when CQ is given alone (3 males and 3 females) or in combination with 1000 mg sustained release MB (3 males and 3 females) in the participants of study part 1 (part 2).

Conditions

  • Methylene Blue
  • Chloroquine
  • Pharmacokinetics
  • Bioavailability

Sponsors & Collaborators

  • Heidelberg University

    lead OTHER

Principal Investigators

  • Gerd Mikus, MD Bsc · Department Internal Medicine VI

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-08-31
Completion
2004-11-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00176072 on ClinicalTrials.gov