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A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole

NCT00164788 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 7

Last updated 2012-08-28

No results posted yet for this study

Summary

The investigators hypothesize that high dose esomeprazole 80mg given as a bolus, followed by 8mg/h would render gastric pH near neutral and that pH control with esomeprazole given in such a high dose either intravenous or orally is identical.

Conditions

  • Gastrointestinal Hemorrhage

Interventions

DRUG

Intravenous bolus injection of esomeprazole

80mg followed by continuous intravenous infusion of 8mg per hour for 24 hours

DRUG

Oral esomeprazole

40mg every 12 hours for 24 hours

Sponsors & Collaborators

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • James YW Lau, MD · Prince of Wales Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-07-31
Primary Completion
2011-01-31
Completion
2011-01-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00164788 on ClinicalTrials.gov