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The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation

NCT00164021 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2016-01-15

No results posted yet for this study

Summary

Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration. Chest physiotherapy may result in increased episodes of GOR as demonstrated in children. Lung transplantation may worsen pre-existing GOR. This study will determine the prevalence, severity and significance of symptomatic and silent GOR in adults with CF before and after lung transplant using 24hr oesophageal pH monitoring, a valid symptom questionnaire, quality of life questionnaires and gastric emptying studies. This study will identify the extent of GOR in a large adult CF population and the impact on lung function and quality of life together with the effects of medical and physiotherapy treatment on gastro-oesophageal function.

Conditions

Interventions

PROCEDURE

Physiotherapy, exercise, percutaneous gastrostomy feeds

DRUG

Anti-reflux pharmacotherapy

Sponsors & Collaborators

  • The Alfred

    collaborator OTHER

  • Monash University

    collaborator OTHER

  • Bayside Health

    lead OTHER_GOV

Principal Investigators

  • Brenda M Button, DPhty, PhD · The Alfred

  • Susannah King · The Alfred

  • Colleen Ash · The Alfred

  • John W Wilson, MBBS, PhD · The Alfred

  • Greg Snell, MBBS · The Alfred

  • Stuart Roberts, MBBS · The Alfred

Eligibility

Min Age
16 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2001-02-28
Primary Completion
2016-12-31

Countries

  • Australia

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00164021 on ClinicalTrials.gov