Copenhagen Arterial Revascularization Randomized Patency and Outcome Trial

Summary

There is a remarkable lack of randomized trials concerning the potential benefit of using arterial conduits for coronary bypass surgery. This is the purpose of the present trial. Exclusive use of arterial conduits might result in improved conduit viability, reduced risk of recurrent angina, myocardial infarction and other cardiac events, reduced need for antianginal medication, improved functional status and possibly improved long term survival. The patients will be followed for ten years after surgery.

Conditions

• Coronary Arteriosclerosis
• Ischemic Heart Disease
• Angina Pectoris

Interventions

PROCEDURE

Total arterial revascularization

Coronary artery bypass grafting using LIMA and RIMA and/or radial artery grafts

PROCEDURE

Conventional revascularization

Coronary artery bypass grafting using LIMA and saphenous vein grafts

Sponsors & Collaborators

• Danish Heart Foundation

  collaborator OTHER

• Lundbeck Foundation

  collaborator OTHER

• Copenhagen Hospital Corporation

  collaborator OTHER

• Rigshospitalet, Denmark

  lead OTHER

Principal Investigators

• Sune Damgaard, MD · Dept. of Cardiothoracic Surgery, Rigshospitalet, Copenhagen

• Daniel A Steinbrüchel, Professor · Dept. of Cardiothoracic Surgery, Rigshospitalet, Copenhagen

• Jens T Lund, Consultant · Dept. of Cardiothoracic Surgery, Rigshospitalet, Copenhagen

• Henning Kelbæk, Consultant · Cardiac Cath. Lab., Rigshospitalet, Copenhagen

• Jan K Madsen, Consultant · Dept. of Cardiology, Gentofte County Hospital, Copenhagen

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-02-28

Primary Completion

2011-02-28

Completion

2015-02-28

Countries

• Denmark

Study Locations