Maintenance Treatment vs. Stepwise Drug Discontinuation in First-Episode Schizophrenia

Summary

After one year neuroleptic maintenance treatment in patients with first episode schizophrenia, neuroleptic treatment will be continued vs. stepwise discontinued (randomized design) over a period of 1 year. Under both conditions prodrome based early intervention take place.

Conditions

• Schizophrenia
• Psychoses

Interventions

OTHER

maintained antipsychotic treatment vs. stepwise drug discontinuation

maintained antipsychotic treatment (in low dose) vs. stepwise drug discontinuation; both supplemented by prodrome-based early intervention; 1 year

Sponsors & Collaborators

• German Federal Ministry of Education and Research

  collaborator OTHER_GOV

• German Research Network On Schizophrenia

  collaborator NETWORK

• Janssen-Cilag Ltd.

  collaborator INDUSTRY

• University of Bonn

  collaborator OTHER

• Humboldt-Universität zu Berlin

  collaborator OTHER

• Ludwig-Maximilians - University of Munich

  collaborator OTHER

• University of Göttingen

  collaborator OTHER

• University of Cologne

  collaborator OTHER

• Mainz University

  collaborator OTHER

• University Hospital Tuebingen

  collaborator OTHER

• Universität Duisburg-Essen

  collaborator OTHER

• University of Mannheim

  collaborator OTHER

• University of Jena

  collaborator OTHER

• Martin-Luther-Universität Halle-Wittenberg

  collaborator OTHER

• RWTH Aachen University

  collaborator OTHER

• University of Wuerzburg

  collaborator OTHER

• Heinrich-Heine University, Duesseldorf

  lead OTHER

Principal Investigators

• Wolfgang Gaebel, Professor · Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University of Düsseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf, Germany

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2001-11-30

Primary Completion

2006-06-30

Completion

2006-06-30

Countries

• Germany

Study Locations