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Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2

NCT00158132 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 199

Last updated 2017-01-12

No results posted yet for this study

Summary

Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Amantadine, a medication that improves muscle control, and propranolol, a medication that lowers blood pressure, may be useful in treating cocaine addiction in individuals with severe cocaine withdrawal symptoms. This study will evaluate the effectiveness of amantadine and propranolol in preventing drug relapse among cocaine addicts.

Conditions

  • Cocaine-Related Disorders

Interventions

DRUG

Propranolol

Propranolol 100mg/day in 3 divided doses

DRUG

Amantadine

Amantadine 100mg three times daily

DRUG

Placebo

Placebo pills

Sponsors & Collaborators

Principal Investigators

  • Helen M. Pettinati, Ph.D. · University of Pennsylvania

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-09-30
Primary Completion
2005-03-31
Completion
2006-02-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00158132 on ClinicalTrials.gov