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Corticosteroid Therapy of Septic Shock - Corticus

NCT00147004 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 500

Last updated 2008-04-24

No results posted yet for this study

Summary

The purpose of the study is to determine whether steroids decrease 28-day mortality in patients with septic shock.

Conditions

  • Shock, Septic

Interventions

DRUG

hydrocortisone sodium succinate

50 mg intravenous bolus every six hours for 5 days, then tapered to 50 mg intravenously every 12 hours for days 6-8, 50 mg every 24 hours for days 9-11 and then stopped

DRUG

Placebo

Sponsors & Collaborators

  • European Society of Intensive Care Medicine

    collaborator OTHER

  • International Sepsis Forum

    collaborator OTHER

  • The Gorham Foundation

    collaborator UNKNOWN

  • Hadassah Medical Organization

    lead OTHER

Principal Investigators

  • Charles L Sprung, MD · Hadasah Medical Organization

  • Djillali Annane, MD · Hopital Raymond Poincare

  • Josef Briegel, MD · Ludwig-Maximilian-Universitaet Muenchen

  • Didier Keh, MD · Charite Campus Virchow-Klinikum

  • Rui Moreno, MD · Hospital de St. António dos Capuchos

  • Didier Pittet, MD · University Hospital, Geneva

  • Mervyn Singer, MD · University College, London

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-03-31
Primary Completion
2005-11-30
Completion
2005-11-30

Countries

  • Austria
  • Belgium
  • France
  • Germany
  • Israel
  • Italy
  • Netherlands
  • Portugal
  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00147004 on ClinicalTrials.gov