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Identification of the Genetic Variants Responsible for Primary Biliary Cirrhosis (PBC)

NCT00145964 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2005-11-29

No results posted yet for this study

Summary

Primary biliary cirrhosis (PBC) is a disease of the liver, which predominantly affects women. It causes slowly progressive liver disease, which eventually causes liver failure, requiring a liver transplant. Several different studies of large patient cohorts indicate that the cause of this disease is likely due to a combination of factors including genetic and environmental. PBC is associated with several other "autoimmune diseases" - recently a gene has been identified to be abnormal in individuals with another autoimmune liver disease, namely rheumatoid arthritis. This gene usually tells the body when to switch off an immune response. This study plans to identify whether individuals diagnosed with PBC have a similar abnormality in this gene called protein Tyrosine Phosphatase.

Conditions

  • Liver Cirrhosis, Biliary
  • Biliary Cirrhosis, Primary

Sponsors & Collaborators

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • E.J.L (Jenny) Heathcote, MD · UHN - Toronto Western Hospital, University of Toronto

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-08-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00145964 on ClinicalTrials.gov