A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
NCT00136461 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2011-03-10
Summary
The purpose of this study is to assess the effects of the combination of all-trans retinoic acid in combination with one of two schedules of Bryostatin 1 in patients with myelodysplasia and acute myelogenous leukemia.
Conditions
- Acute Myelogenous Leukemia
- Myelodysplastic Syndrome
Interventions
- DRUG
-
All-trans retinoic acid
- DRUG
-
Bryostatin 1
Sponsors & Collaborators
-
Brigham and Women's Hospital
collaborator OTHER - lead OTHER
Principal Investigators
-
Richard M. Stone, MD · Dana-Farber Cancer Institute
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1997-05-31
- Primary Completion
- 2000-08-31
- Completion
- 2000-08-31
Countries
- United States
Study Locations
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