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Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

NCT00119990 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2008-12-08

No results posted yet for this study

Summary

During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.

Conditions

  • Peritoneal Dialysis

Interventions

DRUG

Icodextrin (dialysate)

2 liter of extraneal are given with one fill for 4 hours.

DRUG

Physioneal (dialysate) 1.36% and 2.27%

2 liter of Physioneal of 1.36% or 3.86% are given with one fill for 4 hours one two different days.

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Per Ivarsen · Department of Renal Medicine C, Skejby Hospital, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-01-31
Primary Completion
2009-01-31
Completion
2010-01-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00119990 on ClinicalTrials.gov