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Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts

NCT00056771 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3432

Last updated 2018-04-05

No results posted yet for this study

Summary

This study will explore the clinical and hereditary (genetic) features of inherited cataracts. A cataract is a clouding of the eye lens, which focuses light on the back of the eye. When the lens becomes cloudy and does not let light through, vision is impaired. Cataracts may be associated with vision problems alone, or with other problems, such as changes in facial appearance or skin problems. A better understanding of these genetic conditions may help in the development of better diagnostic tests.

Patients with inherited cataracts and their family members may be eligible for this study. Participants will be drawn from patients enrolled in other studies of inherited cataracts at the NEI and collaborating clinics.

Participants will undergo the following tests and procedures:

* Medical and surgical history;
* Verification of diagnosis;
* Construction of a family tree regarding familial vision problems;
* Complete eye examination, including dilation of the pupils and photography of the lens, tests of color vision and field of vision, and of the ability to see in the dark;
* Blood sample collection (20 ml, or 4 teaspoons) for genetic studies of hereditary cataracts.

Conditions

  • Cataract

Sponsors & Collaborators

  • National Eye Institute (NEI)

    lead NIH

Principal Investigators

  • James F Hejtmancik, M.D. · National Eye Institute (NEI)

Eligibility

Min Age
4 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-03-18
Completion
2016-05-25

Countries

  • United States
  • China
  • India
  • Italy
  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00056771 on ClinicalTrials.gov