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Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission

NCT00021671 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 3720

Last updated 2021-11-01

No results posted yet for this study

Summary

The purpose of this study is to see if antibiotic drugs given to treat an infection of the uterus during pregnancy can reduce the chances of HIV being passed from an HIV-positive mother to her baby.

A link between bacterial disease of the vagina, premature birth, infection of the uterus during pregnancy, and the passing of HIV from a mother to her baby has been found. Early treatment of these problems may reduce the risk of passing HIV from an HIV-positive mother to her baby.

\[Note: As of 02/21/03, enrollment into this study was halted because preliminary data showed that the study antibiotics were not effective in preventing mother-to-child HIV transmission.\]

Conditions

  • HIV Infections

Interventions

DRUG

Erythromycin

DRUG

Nevirapine

DRUG

Ampicillin sodium

DRUG

Metronidazole

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Taha E Taha, MD, PhD · Johns Hopkins University

  • Robert Goldenberg, MD · Department of Obstetrics and Gynecology, University of Alabama at Birmingham

Study Design

Purpose
PREVENTION
Masking
DOUBLE

Eligibility

Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Completion
2004-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00021671 on ClinicalTrials.gov