Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease
NCT00004771 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2005-06-24
Summary
OBJECTIVES:
I. Evaluate the effects of androgen suppression with leuprolide and androgen replacement with testosterone enanthate on muscle strength in men with Kennedy's disease or other motor neuron disease.
Conditions
- Spinal Muscular Atrophy
- Amyotrophic Lateral Sclerosis
- Spinobulbar Muscular Atrophy
Interventions
- DRUG
-
leuprolide
- DRUG
-
testosterone
Sponsors & Collaborators
-
Ohio State University
collaborator OTHER -
National Center for Research Resources (NCRR)
lead NIH
Principal Investigators
-
Jerry R. Mendell · Ohio State University
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- MALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1992-10-31
More Related Trials
-
A Study to Assess the Efficacy and Safety of MNK-1411 in Duchenne Muscular Dystrophy
NCT03400852 ·Status: TERMINATED ·Phase: PHASE2
-
Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)
NCT01142856 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluate Safety and Biological Activity of ATYR1940 in Participants With Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Facioscapulohumeral Muscular Dystrophy (FSHD)
NCT02579239 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy
NCT01369901 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral Sclerosis
NCT04293484 ·Status: COMPLETED ·Phase: NA
-
Study of Albuterol and Oxandrolone in Patients With Facioscapulohumeral Dystrophy (FSHD)
NCT00027391 ·Status: COMPLETED ·Phase: NA
-
Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis
NCT01730716 ·Status: UNKNOWN ·Phase: PHASE2
-
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS]
NCT00005674 ·Status: COMPLETED ·Phase: PHASE2
-
Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis (ALS)
NCT01640067 ·Status: COMPLETED ·Phase: PHASE1
-
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for ALS
NCT05003921 ·Status: SUSPENDED ·Phase: PHASE1
-
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial
NCT00035815 ·Status: COMPLETED ·Phase: PHASE3
-
Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosis
NCT06391645 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2/PHASE3
-
Phase 1/2 Study of AOC 1020 in Participants With Facioscapulohumeral Muscular Dystrophy (FSHD)
NCT05747924 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Assess Dystrophin Levels in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) Who Have Been Treated With Ataluren
NCT03796637 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Dose Finding Study of NS-065/NCNP-01 in Boys With Duchenne Muscular Dystrophy (DMD)
NCT02740972 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate RO7204239 in Participants With Facioscapulohumeral Muscular Dystrophy
NCT05548556 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase 3 Study of Ataluren in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)
NCT01826487 ·Status: COMPLETED ·Phase: PHASE3
-
Phase III Randomized, Double-Blind Study of Prednisone for Duchenne Muscular Dystrophy
NCT00004646 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase I Open Label Dose Escalation Trial of RNA-144101 in the Treatment of Geographic Atrophy
NCT01093170 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
NCT05819866 ·Status: RECRUITING ·Phase: PHASE3
-
A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers
NCT01039909 ·Status: WITHDRAWN ·Phase: PHASE1
-
Long-Term Outcomes of Ataluren in Duchenne Muscular Dystrophy
NCT03179631 ·Status: COMPLETED ·Phase: PHASE3
-
Safety, Tolerability, Pharmacokinetics, and Biological Activity of ATYR1940 in Adult Participants With Muscular Dystrophy
NCT02239224 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Repeated Mesenchymal Stem Cell Injections in ALS
NCT04821479 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
NCT05337553 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3