O(6)-Benzylguanine in Treating Patients With Malignant Glioma
NCT00002971 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2018-06-27
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase I trial to study the effectiveness of O(6)-benzylguanine given before surgery to patients who have malignant glioma.
Conditions
Interventions
- DRUG
-
O6-benzylguanine
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
lead OTHER
Principal Investigators
-
Michael Prados, MD · UCSF Medical Center at Parnassus
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Max Age
- 120 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1997-06-19
- Primary Completion
- 2003-02-20
- Completion
- 2009-01-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma
NCT00045721 ·Status: TERMINATED ·Phase: PHASE1
-
Chemotherapy in Treating Patients With Recurrent Malignant Glioma
NCT00002986 ·Status: COMPLETED ·Phase: PHASE1
-
O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas
NCT00669669 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma
NCT00017147 ·Status: COMPLETED ·Phase: PHASE3
-
Oxaliplatin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00005856 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Fenretinide in Treating Patients With Recurrent Malignant Glioma
NCT00006080 ·Status: COMPLETED ·Phase: PHASE2
-
Carboplatin in Patients With Progressive Gliomas
NCT00002749 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Chemoradiation for Resectable Glioblastoma
NCT04209790 ·Status: TERMINATED ·Phase: PHASE2
-
Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM
NCT04489420 ·Status: TERMINATED ·Phase: PHASE1
-
Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma
NCT00087061 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Carmustine in Treating Patients With Recurrent Malignant Glioma
NCT00004028 ·Status: COMPLETED ·Phase: PHASE1
-
Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine
NCT00074607 ·Status: TERMINATED ·Phase: PHASE1
-
More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
NCT01445691 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
NCT01878617 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Irinotecan Plus Carmustine in Treating Patients With Recurrent Primary Malignant Glioma
NCT00002988 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma
NCT05561374 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Randomized Phase 2 With CpG-ODN in Malignant Glioblastoma
NCT00190424 ·Status: COMPLETED ·Phase: PHASE2
-
G207 Followed by Radiation Therapy in Malignant Glioma
NCT00157703 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma
NCT00093613 ·Status: COMPLETED ·Phase: PHASE1
-
Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
NCT03250299 ·Status: TERMINATED ·Phase: PHASE1
-
Sirolimus in Treating Patients With Glioblastoma Multiforme
NCT00047073 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Biological Therapy in Treating Patients With Glioblastoma Multiforme
NCT00003185 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine Therapy in Treating Patients With Malignant Glioma
NCT00612001 ·Status: COMPLETED ·Phase: PHASE1
-
Pyrazoloacridine Plus Carboplatin in Treating Patients With Recurrent Glioma
NCT00005976 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
NCT03152318 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1